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T35991 |
Ent-Prostaglandin E2
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ent-Prostaglandin E2 |
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Enzymatically-derived prostaglandin E2 (PGE2) is an optically pure compound whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGE2 is the opposite enantiomer of P... |
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T37918 |
Prostaglandin E2 isopropyl ester
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Prostaglandin E2 isopropyl ester |
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Prostaglandin E2 (PGE2) isopropyl ester is a more lipophilic form of the free acid, PGE2. PG esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid by end... |
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T36144 |
11β-Prostaglandin E2
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11β-PGE2,11β-Prostaglandin E2 |
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11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.[1] 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-... |
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T36160 |
8-iso Prostaglandin E2
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8-iso Prostaglandin E2 |
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8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with ... |
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T36161 |
8-iso Prostaglandin E2 isopropyl ester
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8-iso Prostaglandin E2 isopropyl ester |
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8-iso PGE2 isopropyl ester is a more lipophilic form of the free acid, 8-iso PGE2. Prostaglandin esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid up... |
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T38342 |
11-deoxy Prostaglandin E2
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11-deoxy Prostaglandin E2 |
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11-deoxy Prostaglandin E2 (11-deoxy PGE2) is a stable, synthetic analog of PGE2 . In contrast to PGE2 which has bronchodilation effects, 11-deoxy PGE2 is a powerful bronchoconstrictor and contracts human respiratory trac... |
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T37839 |
20-hydroxy Prostaglandin E2
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20-hydroxy Prostaglandin E2 |
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20-hydroxy Prostaglandin E2 (20-hydroxy PGE2) is a product of cytochrome P450 metabolism of PGE2 . ω-Oxidation at C-20 followed by β-oxidation and the loss of up to four carbons from the lower side chain is a prominent m... |
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T37996 |
17-phenyl trinor Prostaglandin E2 ethyl amide
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17-phenyl trinor Prostaglandin E2 ethyl amide |
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17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rat... |
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T36154 |
15(S)-15-methyl Prostaglandin E2
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15(S)-15-methyl Prostaglandin E2 |
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15(S)-15-methyl PGE2 is a potent, metabolically stable analog of PGE2. It is a potent gastric antisecretory and antiulcer compound. 15(S)-15-methyl PGE2 binds to human myometrium with twice the affinity of PGE2 and is te... |
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T36168 |
8-iso-16-cyclohexyl-tetranor Prostaglandin E2
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8-iso-16-cyclohexyl-tetranor Prostaglandin E2 |
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8-iso Prostaglandin E2 (8-iso PGE2) is one of several isoprostanes produced from polyunsaturated fatty acids during lipid peroxidation. 8-iso-16-cyclohexyl-tetranor PGE2 is a synthetic analog of 8-iso PGE2. There are no ... |
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T36829 |
9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2
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9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 |
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9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the ... |
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T36045 |
1a,1b-dihomo Prostaglandin E2
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1a,1b-dihomo Prostaglandin E2 |
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1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid . 1a,1b-dihomo PGE2 has also b... |
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T71851 |
5-trans-Prostaglandin E2
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5-trans-Prostaglandin E2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator. It also inhibits platelet aggregation in human PRP. |
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T78582 |
15-keto-Prostaglandin E2
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15-keto-PGE2 |
Prostaglandin Receptor
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15-keto-Prostaglandin E2, an endogenous metabolite, inhibits STAT3 activation through binding to Cys259 and regulates breast cancer cell growth and progression. Additionally, it binds and stabilizes the EP2 and EP4 recep... |
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T83773 |
Prostaglandin E2 Inhibitor 3
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PGE2 Inhibitor 3 |
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Prostaglandin E2 (PGE2) inhibitor 3 is a selective inhibitor targeting microsomal prostaglandin E synthase-1 (mPGES-1; IC50 = 0.2 µM), demonstrating greater selectivity for mPGES-1 over COX-1, COX-2, 5-lipoxygenase (5-LO... |
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T36728 |
9-deoxy-9-methylene Prostaglandin E2
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9-deoxy-9-methylene Prostaglandin E2 |
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9-deoxy-9-methylene Prostaglandin E2 (9-deoxy-9-methylene PGE2) is a stable, isosteric analog of PGE2 . 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects. In the rat 9-deoxy-9-methyl... |
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T10046 |
16,16-Dimethyl prostaglandin E2
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16,16-dimethyl PGE2 |
Prostaglandin Receptor
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16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an interaction with the Wnt pathway. |
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T14975 |
CJ-42794
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CJ-042794 |
Others
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CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-... |
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T83779 |
EP4 Antagonist 14
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Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14 |
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EP4 antagonist 14 is a prostaglandin E2 receptor subtype EP4 antagonist, demonstrating an IC50 of 1.1 nM in a HEK293 human receptor reporter assay and blocking β-arrestin recruitment due to PGE2 with an IC50 of 0.9 nM. A... |
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T3174 |
Taprenepag
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CP-544326 |
Prostaglandin Receptor
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Taprenepag (CP-544326) (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle. |
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T67795 |
Camonagrel
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Camonagrel is a compound that has inhibitory effects on Prostaglandin E2. |
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T8603 |
ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE
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Prostaglandin Receptor
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ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE targets the prostaglandin E2 receptor EP2 subtype (human) |
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T27084 |
Crisdesalazine
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AAD2004,AAD 2004,AAD-2004 |
Prostaglandin Receptor
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Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and incre... |
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T15259 |
Evatanepag
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CP-533536 free acid |
Prostaglandin Receptor
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Evatanepag (CP-533536 free acid) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability to heal fractures when administered l... |
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T36536 |
SH-42
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SH-42 is an inhibitor of 24-dehydrocholesterol reductase (DHCR24; IC50= 4.2 nM).1It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dos... |
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T35610 |
2,5-dimethyl Celecoxib
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Apoptosis
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Wnt/beta-catenin
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Prostaglandin Receptor
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2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... |
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T21493 |
Cyclosporin H
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Others
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Cyclosporin H (CsH), a specific inhibitor of FPR1, inhibited lung inflammation in the ALI models. CsH significantly attenuated MTDs or NFP-induced inflammatory lung injury and activation of MAPK and AKT pathways. Cyclosp... |
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T28755 |
Seprilose
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GW80126,GW 80126,GW-80126 |
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Seprilose, prostaglandin E2 inhibitor, inhibits prostaglandin E2 synthesis. |
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T68983 |
HR-546
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HR-546 is a prostaglandin E2 and prostaglandin F2alpha antagonist. |
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T27981 |
MB-28767
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M&B 28767,MB28767 |
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MB-28767 is an agonist of prostaglandin E2 (PGE2) receptor. |
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T32720 |
Levuglandin E2
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Levuglandin E2 is a secoprostanoid from prostaglandin endoperoxide. |
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T69329 |
AY 23626
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AY 23626 is a Prostaglandin E2 agonist. |
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T33710 |
Nocloprost
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Nocloprost is a prostaglandin E2 analog with local gastroprotective and ulcer-healing activity. |
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T12100 |
MPGES1-IN-3
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Prostaglandin Receptor
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mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) . |
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T15421 |
GSK-269984A
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Others
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GSK-269984A is an antagonist of Prostaglandin E2 Receptor 1 (EP1) (pIC50: 7.9). |
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T69256 |
ONO-AE1-259 lysine
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ONO-AE1-259 is a highly selective agonist of prostaglandin e2 receptor (ep2) |
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T27279 |
ER819762
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ER-819762,ER 819762 |
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ER819762, an antagonist of the prostaglandin E2 EP4 receptor, inhibits Th1 differentiation and Th17 expansion. |
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T11499 |
GSK726701A
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Others
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T81658 |
Nocistatin(human) TFA
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Nocistatin (human) TFA inhibits the allodynia and hyperalgesia induced by nociceptin and mitigates pain triggered by prostaglandin E2 [1]. |
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T13488 |
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
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2-_E-2-decenoylamino_ethyl_2-_cyclohexylethyl__sulfide |
Prostaglandin Receptor
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2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound known to inhibit stress-induced ulcers, effectively maintaining the levels of phospholipase A2 and prostaglandin E2 in rats subjected to water immersio... |
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T69755 |
Evatanepag sodium
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Evatanepag, also known as CP-533536, is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. CP-533536 demonstrated the ability to heal fractures when administered locally as a sin... |
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T22172 |
YS-121
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YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 ( mPGES-1; IC 50 =3.4 μM) and 5-lipoxygenase ( 5-LOX; IC 50 =6.5 μM). YS121 dose-dependently reduces the production of PGE2 with EC 50 =12 μM in IL-1β-s... |
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T36080 |
Rivenprost
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ONO-4819 |
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Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively).... |
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T36004 |
1-O-Hexadecyl-sn-glycerol
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1-O-Hexadecyl-sn-glycerol,(S)-(+)-Chimyl Alcohol,α-Chimyl Alcohol |
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1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether. It reduces UVB-induced cell death and production of reactive oxygen species (ROS) and prostaglandin E2 in normal human epidermal keratinocytes (NHEKs). 1-O-H... |
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T72513 |
SC 51089 free base
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SC 51089 free base is a selective antagonist of the prostaglandin E2 EP1 receptor, demonstrating neuroprotective activity. It exhibits binding affinities (Kis) of 1.3 μM for EP1, 11.2 μM for TP, 17.5 μM for EP3, and 61.1... |
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T36234 |
5(Z),11(Z),14(Z)-Eicosatrienoic Acid
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5(Z),11(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid found in various natural sources including maritime pine (Pinus pinaster) seed oil (MPSO), gymnospermae leaves and seeds, and freshwater gastropods. A ... |
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T71285 |
Metaxalone-d6
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Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264... |
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T38305 |
Tetranor-PGAM
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Prostaglandin E2 (PGE2), one of the most widely investigated PGs, can be used as a biomarker of inflammation, disease state, or therapeutic effectiveness. However due to its rapid metabolism, direct measurement of PGE2 i... |
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T68738 |
(±)-γ-Tocopherol
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(±)-γ-Tocopherol is a form of vitamin E with antioxidant and anti-inflammatory properties. It traps and detoxifies reactive nitrogen oxide species, including nitrogen dioxide, in cell-free assays. It also reduces the syn... |
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T83785 |
2-Chloroadenosine-5'-O-diphosphate sodium
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2-chloro ADP |
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2-Chloroadenosine-5'-O-diphosphate, a purine nucleotide adenosine 5'diphosphate (ADP) derivative, demonstrates multiple biological activities. It promotes aggregation and inhibits cyclic AMP (cAMP) production, triggered ... |
